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KMID : 0352819920080020181
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Kosin Medical Journal
1992 Volume.8 No. 2 p.181 ~ p.196
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Prognostic Significance of Flow Cytometric DNA Analysis in Solid Tumors
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Abstract
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Flow cytometric DNA content analysis is a rapid, quantitative method of determining the DNA ploidy status and proliferative index of a given tumor. Aneuploidy is present in 60-70% of solid tumors and has been recognized as a marker of
malignancy and unfavorable prognosis.
Also, high S-phase fraction has been recognized as an expression of biological aggressiveness and poor prognosis. This method has been applied widely to many kinds of malignant tumors to evaluate it's prognostic significance and possibility of
clinical application. But the results are still contriversial according to the exminers and kinds of tumors. to evaluate prognostic significance of this method in gastric carcinoma we examined DNA ploidy and survival time of 235 gastric
cancer
patients who underwent opertions at the Departement of Surgery, Kosin Medical College between January 1979 and June 1981, and the results were compared with other prognostic factors such as TNM atage, histologic grade, Lauren's
classification
and patients age along with a collective review of recent literatures.
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KEYWORD
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